PrimePCR™ SYBR® Green Assay: BRCA2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0052184

List Price:    $179.00
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PrimePCR™ PreAmp for SYBR® Green Assay: BRCA2, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for SYBR® Green Assay: BRCA2, Human
Reaction:     200 x 20 µl reactions desalted
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding primer assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0044922
Assay Design:   exonic
Chromosome Location:   13:32906728-32906832question
Amplicon Length:   75
Splice Variants Targeted:   ENST00000380152 ENST00000530893 ENST00000544455

Gene Information

Inherited mutations in BRCA1 and this gene BRCA2 confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq Dec 2008]

Gene Symbol:   BRCA2
Gene Name:   breast cancer 2, early onset
Aliases:   BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2
RefSeq:   NC_000013.10 NG_012772.1 NG_017006.1 NT_024524.14
Ensembl:   ENSG00000139618
Entrez:   675
Chromosome Mapping:   13q12.3

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