PrimePCR™ SYBR® Green Assay: ERBB2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

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PrimePCR™ PreAmp for SYBR® Green Assay: ERBB2, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for SYBR® Green Assay: ERBB2, Human
Reaction:     200 x 20 µl reactions desalted
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding primer assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCID0012766
Assay Design:   Intron-spanning
Chromosome Location:   17:37882058-37882860question
Amplicon Length:   65
Splice Variants Targeted:   ENST00000541774 ENST00000445658 ENST00000269571 ENST00000406381 ENST00000540147

Gene Information

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported with the most common allele Ile654/Ile655 shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers including breast and ovarian tumors. Alternative splicing results in several additional transcript variants some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq Jul 2008]

Gene Symbol:   ERBB2
Gene Name:   v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Aliases:   CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
RefSeq:   NC_000017.10 NT_010783.15 NG_007503.1
Ensembl:   ENSG00000141736
Entrez:   2064
Chromosome Mapping:   17q11.2-q12,17q21.1

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