PrimePCR™ SYBR® Green Assay: KCNJ11, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Recommended - best coverage

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0006931
Assay Design:   Exonic
Chromosome Location:   11:17409224-17409313question
Amplicon Length:   60
Splice Variants Targeted:   ENST00000339994 ENST00000528731 ENST00000526912 ENST00000528992

Gene Information

Potassium channels are present in most mammalian cells where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein which has a greater tendency to allow potassium to flow into a cell rather than out of a cell is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI) an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM) transient neonatal diabetes mellitus type 3 (TNDM3) and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq Oct 2009]

Gene Symbol:   KCNJ11
Gene Name:   potassium inwardly-rectifying channel, subfamily J, member 11
Aliases:   BIR, HHF2, IKATP, KIR6.2, MGC133230, PHHI, TNDM3
RefSeq:   NC_000011.9 NG_012446.1 NT_009237.18
Ensembl:   ENSG00000187486
Entrez:   3767
Chromosome Mapping:   11p15.1

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