PrimePCR™ SYBR® Green Assay: CHEK2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCIP0029419

List Price:    $179.00
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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCID0014511
Assay Design:   Intron-spanning
Chromosome Location:   22:29107897-29115459question
Amplicon Length:   156
Splice Variants Targeted:   ENST00000328354 ENST00000404276 ENST00000405598 ENST00000382580 ENST00000403642 ENST00000402731 ENST00000425190 ENST00000439200 ENST00000348295 ENST00000382578 ENST00000544772 ENST00000382566

Gene Information

In response to DNA damage and replication blocks cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated the encoded protein is known to inhibit CDC25C phosphatase preventing entry into mitosis and has been shown to stabilize the tumor suppressor protein p53 leading to cell cycle arrest in G1. In addition this protein interacts with and phosphorylates BRCA1 allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also mutations in this gene are thought to confer a predisposition to sarcomas breast cancer and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Apr 2012]

Gene Symbol:   CHEK2
Gene Name:   CHK2 checkpoint homolog (S. pombe)
Aliases:   CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53
RefSeq:   NC_000022.10 NG_008150.1 NT_011520.12
Ensembl:   ENSG00000183765
Entrez:   11200
Chromosome Mapping:   22q11,22q12.1

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