PrimePCR™ SYBR® Green Assay: FLT3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Recommended - best efficiency

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCID0021972
Assay Design:   Intron-spanning
Chromosome Location:   13:28608498-28609690question
Amplicon Length:   76
Splice Variants Targeted:   ENST00000241453 ENST00000380982 ENST00000537084

Gene Information

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains one transmembrane region and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis proliferation and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq Jul 2008]

Gene Symbol:   FLT3
Gene Name:   fms-related tyrosine kinase 3
Aliases:   CD135, FLK2, STK1
RefSeq:   NC_000013.10 NG_007066.1 NT_024524.14
Ensembl:   ENSG00000122025
Entrez:   2322
Chromosome Mapping:   13q12

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