PrimePCR™ SYBR® Green Assay: FGFR1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0001617
Assay Design:   Exonic
Chromosome Location:   8:38272297-38272393question
Amplicon Length:   67
Splice Variants Targeted:   ENST00000397091 ENST00000532791 ENST00000397113 ENST00000356207 ENST00000335922 ENST00000326324 ENST00000397103 ENST00000397108 ENST00000425967 ENST00000447712 ENST00000341462 ENST00000310729

Gene Information

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors setting in motion a cascade of downstream signals ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome Jackson-Weiss syndrome Antley-Bixler syndrome osteoglophonic dysplasia and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however not all variants have been fully characterized. [provided by RefSeq Jul 2008]

Gene Symbol:   FGFR1
Gene Name:   fibroblast growth factor receptor 1
Aliases:   BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLJ99988, FLT-2, FLT2, HBGFR, KAL2, N-SAM, OGD, bFGF-R-1
RefSeq:   NC_000008.10 NT_167187.1 NG_007729.1
Ensembl:   ENSG00000077782
Entrez:   2260
Chromosome Mapping:   8p12

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