PrimePCR™ SYBR® Green Assay: CFI, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCEP0055769

List Price:    $179.00
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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0048509
Assay Design:   exonic
Chromosome Location:   4:110685842-110687817question
Amplicon Length:   83
Splice Variants Targeted:   ENST00000394635 ENST00000512148 ENST00000510800 ENST00000394634

Gene Information

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome a disease characterized by acute renal failure microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   CFI
Gene Name:   complement factor I
Aliases:   AHUS3, C3BINA, C3b-INA, FI, IF, KAF
RefSeq:   NC_000004.11 NG_007569.1 NT_016354.19
Ensembl:   ENSG00000205403
Entrez:   3426
Chromosome Mapping:   4q25

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