PrimePCR™ SYBR® Green Assay: ETV1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCIP0028470

List Price:    $179.00
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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCID0012502
Assay Design:   Intron-spanning
Chromosome Location:   7:13935603-13940430question
Amplicon Length:   148
Splice Variants Targeted:   ENST00000430479 ENST00000405192 ENST00000405358 ENST00000403527 ENST00000405218 ENST00000403685 ENST00000242066 ENST00000343495 ENST00000420159 ENST00000399357

Gene Information

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth angiogenesis migration proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377 Table 1) in prostate cancer. In addition to chromosomal rearrangement this gene is overexpressed in prostate cancer melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Aug 2011]

Gene Symbol:   ETV1
Gene Name:   ets variant 1
Aliases:   DKFZp781L0674, ER81, MGC104699, MGC120533, MGC120534
RefSeq:   NC_000007.13 NT_007819.17
Ensembl:   ENSG00000006468
Entrez:   2115
Chromosome Mapping:   7p21.3

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