PrimePCR™ SYBR® Green Assay: COMT, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Recommended - best coverage

List Price:    $179.00
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PrimePCR™ PreAmp for SYBR® Green Assay: COMT, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for SYBR® Green Assay: COMT, Human
Reaction:     200 x 20 µl reactions desalted
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding primer assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0001845
Assay Design:   Exonic
Chromosome Location:   22:19951721-19951810question
Amplicon Length:   60
Splice Variants Targeted:   ENST00000361682 ENST00000403184 ENST00000403710 ENST00000407537 ENST00000412786 ENST00000406520 ENST00000428707 ENST00000449653

Gene Information

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines including the neurotransmitters dopamine epinephrine and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances COMT is important in the metabolism of catechol drugs used in the treatment of hypertension asthma and Parkinson disease. COMT is found in two forms in tissues a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq Sep 2008]

Gene Symbol:   COMT
Gene Name:   catechol-O-methyltransferase
Aliases:   Not Available
RefSeq:   NC_000022.10 NG_011526.1 NG_011835.1 NG_023326.1 NT_011519.10
Ensembl:   ENSG00000093010
Entrez:   1312
Chromosome Mapping:   22q11.21-q11.23,22q11.21

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