PrimePCR™ SYBR® Green Assay: PTPN11, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCIP0033527

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PrimePCR™ PreAmp for SYBR® Green Assay: PTPN11, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for SYBR® Green Assay: PTPN11, Human
Reaction:     200 x 20 µl reactions desalted
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding primer assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCID0022662
Assay Design:   Intron-spanning
Chromosome Location:   12:112891117-112892434question
Amplicon Length:   112
Splice Variants Targeted:   ENST00000392597 ENST00000351677 ENST00000530818 ENST00000392596

Gene Information

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitotic cycle and oncogenic transformation. This PTP contains two tandem Src homology-2 domains which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions such as mitogenic activation metabolic control transcription regulation and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq Jul 2008]

Gene Symbol:   PTPN11
Gene Name:   protein tyrosine phosphatase, non-receptor type 11
Aliases:   BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
RefSeq:   NC_000012.11 NG_007459.1 NT_009775.17
Ensembl:   ENSG00000179295
Entrez:   5781
Chromosome Mapping:   12q24

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