PrimePCR™ SYBR® Green Assay: Cldn16, Mouse

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qMmuCID0005148
Assay Design:   Intron-spanning
Chromosome Location:   16:26477555-26481234question
Amplicon Length:   112
Splice Variants Targeted:   ENSMUST00000161053 ENSMUST00000115302

Gene Information

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is critical for renal paracellular epithelial transport of Ca(2+) and Mg(2+) in the thick ascending loop of Henle. The gene deficiency leads to specific alterations in renal Ca(2+) and Mg(2+) balance and also to disturbances in Na(+) handling. The interaction of this gene and the Cldn 19 gene is required for their assembly into tight junctions and for renal Mg(2+) reabsorption. This gene and the Cldn1 gene are clustered on chromosome 16. [provided by RefSeq Aug 2010]

Gene Symbol:   Cldn16
Gene Name:   Claudin 16
Aliases:   PCLN1, claudin-16
RefSeq:   NC_000082.6 NT_039624.8
Ensembl:   ENSMUSG00000038148
Entrez:   114141
Chromosome Mapping:   16|16 B2

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