PrimePCR™ SYBR® Green Assay: Dio1, Mouse

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qMmuCID0014619
Assay Design:   Intron-spanning
Chromosome Location:   4:107293913-107306851question
Amplicon Length:   76
Splice Variants Targeted:   ENSMUST00000082426 ENSMUST00000129138

Gene Information

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 33'5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). This protein contains a selenocysteine (Sec) residue which is necessary for maximal enzyme activity. The selenocysteine is encoded by the UGA codon which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure the sec insertion sequence (SECIS) which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Impaired expression of this gene results in hypothyroidism which causes severe defects in the development of many different tissues. [provided by RefSeq Jul 2008]

Gene Symbol:   Dio1
Gene Name:   Deiodinase, iodothyronine, type I
Aliases:   5DI, D1, ITDI1, TXDI1
RefSeq:   NC_000070.6 NT_039264.7
Ensembl:   ENSMUSG00000034785
Entrez:   13370
Chromosome Mapping:   4 C7|4 48.7 cM

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