PrimePCR™ SYBR® Green Assay: FEN1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCEP0039485

List Price:    $179.00
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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0036761
Assay Design:   exonic
Chromosome Location:   11:61564544-61564672question
Amplicon Length:   99
Splice Variants Targeted:   ENST00000305885 ENST00000535307

Gene Information

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore secondary structure can deter the protective function of this protein leading to site-specific trinucleotide expansions. [provided by RefSeq Jul 2008]

Gene Symbol:   FEN1
Gene Name:   flap structure-specific endonuclease 1
Aliases:   FEN-1, MF1, RAD2
RefSeq:   NC_000011.9 NT_167190.1
Ensembl:   ENSG00000168496
Entrez:   2237
Chromosome Mapping:   11q12

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