PrimePCR™ SYBR® Green Assay: PML, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCID0022375
Assay Design:   Intron-spanning
Chromosome Location:   15:74290739-74315200question
Amplicon Length:   81
Splice Variants Targeted:   ENST00000268058 ENST00000395132 ENST00000268059 ENST00000354026 ENST00000418568 ENST00000395135 ENST00000435786 ENST00000359928 ENST00000436891

Gene Information

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains a RING a B-box type 1 and a B-box type 2 and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Jul 2008]

Gene Symbol:   PML
Gene Name:   promyelocytic leukemia
Aliases:   MYL, PP8675, RNF71, TRIM19
RefSeq:   NC_000015.9 NT_010194.17
Ensembl:   ENSG00000140464
Entrez:   5371
Chromosome Mapping:   15q22

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