PrimePCR™ SYBR® Green Assay: WAS, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCEP0025099

List Price:    $179.00
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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0004639
Assay Design:   Exonic
Chromosome Location:   X:48546689-48546812question
Amplicon Length:   94
Splice Variants Targeted:   ENST00000376701

Gene Information

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli and interact with multiple proteins. Recent studies have demonstrated that these proteins directly or indirectly associate with the small GTPase Cdc42 known to regulate formation of actin filaments and the cytoskeletal organizing complex Arp2/3. Wiskott-Aldrich syndrome is a rare inherited X-linked recessive disease characterized by immune dysregulation and microthrombocytopenia and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein expressed exclusively in hematopoietic cells which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage and containing a different 5' UTR sequence has been described however its full-length nature is not known. [provided by RefSeq Jul 2008]

Gene Symbol:   WAS
Gene Name:   Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
Aliases:   IMD2, THC, THC1, WASP
RefSeq:   NC_000023.10 NG_007877.1 NT_079573.4
Ensembl:   ENSG00000015285
Entrez:   7454
Chromosome Mapping:   Xp11.4-p11.21

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