PrimePCR™ SYBR® Green Assay: CXCR2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCEP0033530

List Price:    $179.00
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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0022673
Assay Design:   Exonic
Chromosome Location:   2:218999747-218999901question
Amplicon Length:   125
Splice Variants Targeted:   ENST00000453237 ENST00000415392 ENST00000318507 ENST00000454148 ENST00000428565

Gene Information

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA) a protein with melanoma growth stimulating activity and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene IL8RA a gene encoding another high affinity IL8 receptor as well as IL8RBP a pseudogene of IL8RB form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq Nov 2009]

Gene Symbol:   CXCR2
Gene Name:   chemokine (C-X-C motif) receptor 2
Aliases:   CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
RefSeq:   NC_000002.11 NT_005403.17
Ensembl:   ENSG00000180871
Entrez:   3579
Chromosome Mapping:   2q35

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