PrimePCR™ SYBR® Green Assay: PTEN, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCEP0039520

List Price:    $179.00
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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0036796
Assay Design:   exonic
Chromosome Location:   10:89726222-89726368question
Amplicon Length:   117
Splice Variants Targeted:   ENST00000371953

Gene Information

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-345-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-345-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq Jul 2008]

Gene Symbol:   PTEN
Gene Name:   phosphatase and tensin homolog
Aliases:   10q23del, BZS, DEC, GLM2, MGC11227, MHAM, MMAC1, PTEN1, TEP1
RefSeq:   NC_000010.10 NG_007466.1 NT_030059.13
Ensembl:   ENSG00000171862
Entrez:   5728
Chromosome Mapping:   10q23.3

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