PrimePCR™ SYBR® Green Assay: GRIA2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCEP0057634

List Price:    $179.00
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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0056529
Assay Design:   exonic
Chromosome Location:   4:158257014-158257651question
Amplicon Length:   109
Splice Variants Targeted:   ENST00000507898 ENST00000393815 ENST00000296526 ENST00000264426 ENST00000449365

Gene Information

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and function as ligand-activated cation channels. These channels are assembled from 4 related subunits GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing resulting in transcript variants encoding different isoforms (including the flip and flop isoforms that vary in their signal transduction properties) has been noted for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   GRIA2
Gene Name:   glutamate receptor, ionotropic, AMPA 2
Aliases:   GLUR2, GLURB, GluA2, GluR-K2, HBGR2
RefSeq:   NC_000004.11 NT_016354.19
Ensembl:   ENSG00000120251
Entrez:   2891
Chromosome Mapping:   4q32-q33

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