PrimePCR™ SYBR® Green Assay: CASP3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCIP0029139

List Price:    $179.00
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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCID0013989
Assay Design:   Intron-spanning
Chromosome Location:   4:185553490-185556561question
Amplicon Length:   145
Splice Variants Targeted:   ENST00000308394 ENST00000393585 ENST00000523916 ENST00000517513 ENST00000393588 ENST00000447121 ENST00000438467

Gene Information

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits large and small that dimerize to form the active enzyme. This protein cleaves and activates caspases 6 7 and 9 and the protein itself is processed by caspases 8 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq Jul 2008]

Gene Symbol:   CASP3
Gene Name:   caspase 3, apoptosis-related cysteine peptidase
Aliases:   CPP32, CPP32B, SCA-1
RefSeq:   NC_000004.11 NT_016354.19
Ensembl:   ENSG00000164305
Entrez:   836
Chromosome Mapping:   4q34

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