PrimePCR™ SYBR® Green Assay: DYRK1A, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Same primer pair as used in probe assay qHsaCIP0027525

List Price:    $179.00
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PrimePCR™ PreAmp for SYBR® Green Assay: DYRK1A, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for SYBR® Green Assay: DYRK1A, Human
Reaction:     200 x 20 µl reactions desalted
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding primer assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCID0010296
Assay Design:   Intron-spanning
Chromosome Location:   21:38865421-38868504question
Amplicon Length:   100
Splice Variants Targeted:   ENST00000338785 ENST00000339659 ENST00000398960 ENST00000398956 ENST00000321219 ENST00000451934 ENST00000455387

Gene Information

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence a protein kinase domain a leucine zipper motif and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21 and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq Jul 2008]

Gene Symbol:   DYRK1A
Gene Name:   dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Aliases:   DYRK, DYRK1, HP86, MNB, MNBH
RefSeq:   NC_000021.8 NT_011512.11 NG_009366.1
Ensembl:   ENSG00000157540
Entrez:   1859
Chromosome Mapping:   21q22.13

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