PrimePCR™ SYBR® Green Assay: Trp73, Mouse

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qMmuCID0006017
Assay Design:   Intron-spanning
Chromosome Location:   4:154064673-154067041question
Amplicon Length:   77
Splice Variants Targeted:   ENSMUST00000133533 ENSMUST00000105644 ENSMUST00000097762 ENSMUST00000105643 ENSMUST00000155642

Gene Information

This gene encodes tumor protein p73 which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53 p63 and p73 and have high sequence similarity to one another which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters alternate translation initiation sites and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq Jul 2008]

Gene Symbol:   Trp73
Gene Name:   Transformation related protein 73
Aliases:   Tp73, p73
RefSeq:   NC_000070.6 NT_187033.1
Ensembl:   ENSMUSG00000029026
Entrez:   22062
Chromosome Mapping:   4 E2|4 82.0 cM

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