PrimePCR™ SYBR® Green Assay: CLDN11, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0023786
Assay Design:   Exonic
Chromosome Location:   3:170151558-170151759question
Amplicon Length:   172
Splice Variants Targeted:   ENST00000064724

Gene Information

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB) and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq Aug 2010]

Gene Symbol:   CLDN11
Gene Name:   claudin 11
Aliases:   OSP, OTM
RefSeq:   NC_000003.11 NT_005612.16
Ensembl:   ENSG00000013297
Entrez:   5010
Chromosome Mapping:   3q26.2-q26.3

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