PrimePCR™ Probe Assay: PSENEN, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: PSENEN, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: PSENEN, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0032553
Assay Design:   Exonic
Chromosome Location:   19:36237336-36237713question
Amplicon Length:   164
Splice Variants Targeted:   ENST00000222266

Gene Information

Presenilins which are components of the gamma-secretase protein complex are required for intramembranous processing of some type I transmembrane proteins such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling and for the activity and accumulation of gamma-secretase. [provided by RefSeq Jul 2008]

Gene Symbol:   PSENEN
Gene Name:   presenilin enhancer 2 homolog (C. elegans)
Aliases:   MSTP064, PEN-2, PEN2
RefSeq:   NC_000019.9 NG_027934.1 NT_011109.16
Ensembl:   ENSG00000205155
Entrez:   55851
Chromosome Mapping:   19q13.12

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