PrimePCR™ Probe Assay: SMAD7, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: SMAD7, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: SMAD7, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0050142
Assay Design:   exonic
Chromosome Location:   18:46448096-46448245question
Amplicon Length:   120
Splice Variants Targeted:   ENST00000262158 ENST00000591805 ENST00000589634 ENST00000586093

Gene Information

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding this complex translocates to the cytoplasm where it interacts with TGF-beta receptor type-1 (TGFBR1) leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jun 2010]

Gene Symbol:   SMAD7
Gene Name:   SMAD family member 7
Aliases:   CRCS3, FLJ16482, MADH7, MADH8
RefSeq:   NC_000018.9 NT_010966.14 NG_023330.1
Ensembl:   ENSG00000101665
Entrez:   4092
Chromosome Mapping:   18q21.1

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