PrimePCR™ Probe Assay: LFNG, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: LFNG, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: LFNG, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0050383
Assay Design:   exonic
Chromosome Location:   7:2565399-2565963question
Amplicon Length:   62
Splice Variants Targeted:   ENST00000402506 ENST00000402045 ENST00000222725 ENST00000359574 ENST00000338732

Gene Information

This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases fringe proteins have a fucose-specific beta-13-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Oct 2009]

Gene Symbol:   LFNG
Gene Name:   LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Aliases:   SCDO3
RefSeq:   NC_000007.13 NT_007819.17 NG_008109.1
Ensembl:   ENSG00000106003
Entrez:   3955
Chromosome Mapping:   7p22.2

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