PrimePCR™ Probe Assay: HTR2C, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: HTR2C, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: HTR2C, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0026057
Assay Design:   Intron-spanning
Chromosome Location:   X:113965937-114082659question
Amplicon Length:   144
Splice Variants Targeted:   ENST00000371950 ENST00000276198 ENST00000371951

Gene Information

Serotonin (5-hydroxytryptamine 5-HT) a neurotransmitter elicits a wide array of physiological effects by binding to several receptor subtypes including the 5-HT2 family of seven-transmembrane-spanning G-protein-coupled receptors which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq Feb 2012]

Gene Symbol:   HTR2C
Gene Name:   5-hydroxytryptamine (serotonin) receptor 2C
Aliases:   5-HT2C, 5-HTR2C, HTR1C
RefSeq:   NC_000023.10 NG_012082.1 NT_028405.12
Ensembl:   ENSG00000147246
Entrez:   3358
Chromosome Mapping:   Xq24

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