PrimePCR™ Probe Assay: GCK, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: GCK, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: GCK, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0029551
Assay Design:   Intron-spanning
Chromosome Location:   7:44187367-44189572question
Amplicon Length:   140
Splice Variants Targeted:   ENST00000403799 ENST00000395796 ENST00000345378 ENST00000437084

Gene Information

Hexokinases phosphorylate glucose to produce glucose-6-phosphate the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM) maturity onset diabetes of the young type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq Apr 2009]

Gene Symbol:   GCK
Gene Name:   glucokinase (hexokinase 4)
Aliases:   FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
RefSeq:   NC_000007.13 NG_008847.1 NT_007819.17
Ensembl:   ENSG00000106633
Entrez:   2645
Chromosome Mapping:   7p15.3-p15.1

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