PrimePCR™ Probe Assay: SMAD4, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0030084
Assay Design:   Intron-spanning
Chromosome Location:   18:48573582-48575111question
Amplicon Length:   110
Splice Variants Targeted:   ENST00000398417 ENST00000342988 ENST00000544926 ENST00000452201

Gene Information

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer juvenile polyposis syndrome and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq Oct 2009]

Gene Symbol:   SMAD4
Gene Name:   SMAD family member 4
Aliases:   DPC4, JIP, MADH4
RefSeq:   NC_000018.9 NG_013013.1 NT_010966.14
Ensembl:   ENSG00000141646
Entrez:   4089
Chromosome Mapping:   18q21.1

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