PrimePCR™ Probe Assay: TGFB1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: TGFB1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: TGFB1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0030973
Assay Design:   Intron-spanning
Chromosome Location:   19:41850663-41854265question
Amplicon Length:   143
Splice Variants Targeted:   ENST00000221930

Gene Information

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines which are multifunctional peptides that regulate proliferation differentiation adhesion migration and other functions in many cell types. Many cells have TGFB receptors and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide and is found in either a latent form composed of a TGFB1 homodimer a LAP homodimer and a latent TGFB1-binding protein or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq Oct 2009]

Gene Symbol:   TGFB1
Gene Name:   transforming growth factor, beta 1
Aliases:   CED, DPD1, LAP, TGFB, TGFbeta
RefSeq:   NC_000019.9 NG_013091.1 NG_013364.1 NT_011109.16
Ensembl:   ENSG00000105329
Entrez:   7040
Chromosome Mapping:   19q13.2,19q13.1

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