PrimePCR™ Probe Assay: BMPR1B, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: BMPR1B, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: BMPR1B, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0033008
Assay Design:   Intron-spanning
Chromosome Location:   4:96025658-96035959question
Amplicon Length:   120
Splice Variants Targeted:   ENST00000515059 ENST00000506363 ENST00000512312 ENST00000509540 ENST00000502683 ENST00000264568 ENST00000394931 ENST00000440890

Gene Information

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors but they require their respective type I receptors for signaling whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq Feb 2012]

Gene Symbol:   BMPR1B
Gene Name:   bone morphogenetic protein receptor, type IB
Aliases:   ALK-6, ALK6, CDw293
RefSeq:   NC_000004.11 NG_009245.1 NT_016354.19
Ensembl:   ENSG00000138696
Entrez:   658
Chromosome Mapping:   4q22-q24

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