PrimePCR™ Probe Assay: CREBBP, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: CREBBP, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: CREBBP, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0033238
Assay Design:   Intron-spanning
Chromosome Location:   16:3786722-3788608question
Amplicon Length:   114
Splice Variants Targeted:   ENST00000262367 ENST00000543883 ENST00000382070 ENST00000323508

Gene Information

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB) this gene is now known to play critical roles in embryonic development growth control and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain cysteine-histidine-rich regions and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq Feb 2009]

Gene Symbol:   CREBBP
Gene Name:   CREB binding protein
Aliases:   CBP, KAT3A, RSTS
RefSeq:   NC_000016.9 NT_010393.16 NG_009873.1
Ensembl:   ENSG00000005339
Entrez:   1387
Chromosome Mapping:   16p13.3

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