PrimePCR™ Probe Assay: DCTN1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0024269
Assay Design:   Exonic
Chromosome Location:   2:74597752-74597925question
Amplicon Length:   144
Splice Variants Targeted:   ENST00000361874 ENST00000409438 ENST00000409240 ENST00000409868 ENST00000409567 ENST00000394003 ENST00000393999 ENST00000407639

Gene Information

This gene encodes the largest subunit of dynactin a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions including ER-to-Golgi transport the centripetal movement of lysosomes and endosomes spindle formation chromosome movement nuclear positioning and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq Oct 2008]

Gene Symbol:   DCTN1
Gene Name:   dynactin 1
Aliases:   DAP-150, DP-150, HMN7B, P135
RefSeq:   NC_000002.11 NT_022184.15 NG_008735.1
Ensembl:   ENSG00000204843
Entrez:   1639
Chromosome Mapping:   2p13

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