PrimePCR™ Probe Assay: UCP1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0050537
Assay Design:   exonic
Chromosome Location:   4:141481062-141481158question
Amplicon Length:   67
Splice Variants Targeted:   ENST00000262999

Gene Information

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue a specialized tissue which functions to produce heat. [provided by RefSeq Jul 2008]

Gene Symbol:   UCP1
Gene Name:   uncoupling protein 1 (mitochondrial, proton carrier)
Aliases:   SLC25A7, UCP
RefSeq:   NC_000004.11 NG_012139.1 NT_016354.19
Ensembl:   ENSG00000109424
Entrez:   7350
Chromosome Mapping:   4q28-q31

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