PrimePCR™ Probe Assay: KLKB1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0053474
Assay Design:   exonic
Chromosome Location:   4:187149406-187153408question
Amplicon Length:   100
Splice Variants Targeted:   ENST00000511608 ENST00000428196 ENST00000264690 ENST00000446598 ENST00000414291 ENST00000513864

Gene Information

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation fibrinolysis kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq Jul 2008]

Gene Symbol:   KLKB1
Gene Name:   kallikrein B, plasma (Fletcher factor) 1
Aliases:   KLK3, PPK
RefSeq:   NC_000004.11 NG_012095.1 NT_016354.19
Ensembl:   ENSG00000164344
Entrez:   3818
Chromosome Mapping:   4q35

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