PrimePCR™ Probe Assay: CDH5, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0030496
Assay Design:   Intron-spanning
Chromosome Location:   16:66432371-66434721question
Amplicon Length:   112
Splice Variants Targeted:   ENST00000341529 ENST00000379531 ENST00000539262 ENST00000539168

Gene Information

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq Jul 2008]

Gene Symbol:   CDH5
Gene Name:   cadherin 5, type 2 (vascular endothelium)
Aliases:   7B4, CD144, FLJ17376
RefSeq:   NC_000016.9 NT_010498.15
Ensembl:   ENSG00000179776
Entrez:   1003
Chromosome Mapping:   16q22.1

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