PrimePCR™ Probe Assay: IL12B, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0030603
Assay Design:   Intron-spanning
Chromosome Location:   5:158745838-158747359question
Amplicon Length:   80
Splice Variants Targeted:   ENST00000231228

Gene Information

This gene encodes a subunit of interleukin 12 a cytokine that acts on T and natural killer cells and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS) suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq Jul 2008]

Gene Symbol:   IL12B
Gene Name:   interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Aliases:   CLMF, CLMF2, IL-12B, NKSF, NKSF2
RefSeq:   NC_000005.9 NG_009618.1 NT_023133.13
Ensembl:   ENSG00000113302
Entrez:   3593
Chromosome Mapping:   5q31.1-q33.1

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