PrimePCR™ Probe Assay: NF1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0031526
Assay Design:   Intron-spanning
Chromosome Location:   17:29541505-29546098question
Amplicon Length:   145
Splice Variants Targeted:   ENST00000456735 ENST00000431387 ENST00000358273 ENST00000356175

Gene Information

This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1 juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   NF1
Gene Name:   neurofibromin 1
Aliases:   DKFZp686J1293, FLJ21220, NFNS, VRNF, WSS
RefSeq:   NC_000017.10 NG_009018.1 NT_010799.15
Ensembl:   ENSG00000196712
Entrez:   4763
Chromosome Mapping:   17q11.2

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