PrimePCR™ Probe Assay: NCF4, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0032863
Assay Design:   Intron-spanning
Chromosome Location:   22:37272044-37273709question
Amplicon Length:   103
Splice Variants Targeted:   ENST00000248899 ENST00000397147 ENST00000415063

Gene Information

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox) which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq Jul 2008]

Gene Symbol:   NCF4
Gene Name:   neutrophil cytosolic factor 4, 40kDa
Aliases:   MGC3810, NCF, P40PHOX, SH3PXD4
RefSeq:   NC_000022.10 NT_011520.12 NG_023400.1
Ensembl:   ENSG00000100365
Entrez:   4689
Chromosome Mapping:   22q13.1

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