PrimePCR™ Probe Assay: IL1B, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0033362
Assay Design:   Intron-spanning
Chromosome Location:   2:113591063-113593767question
Amplicon Length:   119
Splice Variants Targeted:   ENST00000263341 ENST00000418817 ENST00000432018 ENST00000416750

Gene Information

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response and is involved in a variety of cellular activities including cell proliferation differentiation and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq Jul 2008]

Gene Symbol:   IL1B
Gene Name:   interleukin 1, beta
Aliases:   IL-1, IL1-BETA, IL1F2
RefSeq:   NC_000002.11 NG_008851.1 NT_022135.16
Ensembl:   ENSG00000125538
Entrez:   3553
Chromosome Mapping:   2q14

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