Gene:  C5, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene is the fifth component of complement which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide C5a which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component and this complex is the basis for formation of the membrane attack complex which includes additional complement components. Mutations in this gene cause complement component 5 deficiency a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: C5, Rat
Complement C5 C5a anaphylatoxin

Assay Type: SYBR® Green
Assay Design: intron_spanning
Application: Gene Expression
Unique Assay ID: qRnoCID0002027
List Price:    $174.00
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PrimePCR™ Probe Assay: C5, Rat
Complement C5 C5a anaphylatoxin

Assay Type: Probe
Assay Design: intron_spanning
Application: Gene Expression
Unique Assay ID: qRnoCIP0023858
List Price:    $255.00
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