PrimePCR™ Probe Assay: TLR6, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0039547
Assay Design:   exonic
Chromosome Location:   4:38830994-38831134question
Amplicon Length:   111
Splice Variants Targeted:   ENST00000381950 ENST00000508254 ENST00000514655 ENST00000436693

Gene Information

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq Jan 2011]

Gene Symbol:   TLR6
Gene Name:   toll-like receptor 6
Aliases:   CD286
RefSeq:   NC_000004.11 NG_028087.1 NT_016297.16
Ensembl:   ENSG00000174130
Entrez:   10333
Chromosome Mapping:   4p14

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