PrimePCR™ Probe Assay: MDM2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0051885
Assay Design:   exonic
Chromosome Location:   12:69233407-69233529question
Amplicon Length:   93
Splice Variants Targeted:   ENST00000462284 ENST00000258148 ENST00000393410 ENST00000299252 ENST00000360430 ENST00000517852 ENST00000545204 ENST00000393413 ENST00000350057 ENST00000348801 ENST00000478070 ENST00000258149 ENST00000356290 ENST00000540827 ENST00000428863 ENST00000393412

Gene Information

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53 as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53 diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle apoptosis and tumorigenesis through interactions with other proteins including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq Jul 2008]

Gene Symbol:   MDM2
Gene Name:   Mdm2 p53 binding protein homolog (mouse)
Aliases:   HDMX, MGC5370, MGC71221, hdm2
RefSeq:   NC_000012.11 NG_016708.1 NT_029419.12
Ensembl:   ENSG00000135679
Entrez:   4193
Chromosome Mapping:   12q14.3-q15

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