PrimePCR™ Probe Assay: TYMS, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: TYMS, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: TYMS, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0054470
Assay Design:   exonic
Chromosome Location:   18:670711-670833question
Amplicon Length:   93
Splice Variants Targeted:   ENST00000323274 ENST00000323250 ENST00000323224

Gene Information

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 510-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil 5-fluoro-2-prime-deoxyuridine and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq Jul 2008]

Gene Symbol:   TYMS
Gene Name:   thymidylate synthetase
Aliases:   HST422, MGC88736, TMS, TS
RefSeq:   NC_000018.9 NT_010859.14
Ensembl:   ENSG00000176890
Entrez:   7298
Chromosome Mapping:   18p11.32

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