PrimePCR™ Probe Assay: MMP3, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0026053
Assay Design:   Intron-spanning
Chromosome Location:   11:102711183-102712920question
Amplicon Length:   148
Splice Variants Targeted:   ENST00000299855

Gene Information

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development reproduction and tissue remodeling as well as in disease processes such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin laminin collagens III IV IX and X and cartilage proteoglycans. The enzyme is thought to be involved in wound repair progression of atherosclerosis and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq Jul 2008]

Gene Symbol:   MMP3
Gene Name:   matrix metallopeptidase 3 (stromelysin 1, progelatinase)
Aliases:   CHDS6, MGC126102, MGC126103, MGC126104, MMP-3, SL-1, STMY, STMY1, STR1
RefSeq:   NC_000011.9 NG_012100.1 NT_033899.8
Ensembl:   ENSG00000149968
Entrez:   4314
Chromosome Mapping:   11q22.3

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