PrimePCR™ Probe Assay: OAS1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0026992
Assay Design:   Intron-spanning
Chromosome Location:   12:113344987-113346427question
Amplicon Length:   95
Splice Variants Targeted:   ENST00000202917 ENST00000445409 ENST00000452357 ENST00000549820 ENST00000551241 ENST00000553185 ENST00000550689 ENST00000377508

Gene Information

This gene encodes a member of the 2-5A synthetase family essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2'5'-oligoadenylates (2-5As). These molecules activate latent RNase L which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq Jul 2008]

Gene Symbol:   OAS1
Gene Name:   2',5'-oligoadenylate synthetase 1, 40/46kDa
Aliases:   IFI-4, OIAS, OIASI
RefSeq:   NC_000012.11 NT_009775.17 NG_011530.1
Ensembl:   ENSG00000089127
Entrez:   4938
Chromosome Mapping:   12q24.1

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