PrimePCR™ Probe Assay: PRKG1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0055014
Assay Design:   exonic
Chromosome Location:   10:54041991-54048514question
Amplicon Length:   85
Splice Variants Targeted:   ENST00000373985 ENST00000373980 ENST00000373975 ENST00000401604

Gene Information

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha Ibeta and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4 PRKG2 encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone preventing platelet aggregation and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle platelets cerebellar Purkinje cells hippocampal neurons and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq Sep 2011]

Gene Symbol:   PRKG1
Gene Name:   protein kinase, cGMP-dependent, type I
Aliases:   CGKI, DKFZp686K042, FLJ36117, MGC71944, PGK, PKG, PRKG1B, PRKGR1B, cGKI-BETA, cGKI-alpha
RefSeq:   NC_000010.10 NT_030059.13
Ensembl:   ENSG00000185532
Entrez:   5592
Chromosome Mapping:   10q11.2

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