Gene:  F8, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes coagulation factor VIII which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which in the presence of Ca+2 and phospholipids converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein isoform a which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein isoform b which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A a common recessive X-linked coagulation disorder. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: F8, Rat
Coagulation factor VIII precursor

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qRnoCED0053649
List Price:    $174.00
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PrimePCR™ Probe Assay: F8, Rat
Coagulation factor VIII precursor

Assay Type: Probe
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qRnoCEP0047469
List Price:    $255.00
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