PrimePCR™ SYBR® Green Assay: APAF1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0051145

List Price:    $179.00
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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0043883
Assay Design:   exonic
Chromosome Location:   12:99042458-99042575question
Amplicon Length:   88
Splice Variants Targeted:   ENST00000551964 ENST00000359972 ENST00000547743 ENST00000552268 ENST00000550527 ENST00000547045 ENST00000549007 ENST00000357310 ENST00000339433 ENST00000333991

Gene Information

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain a caspase recruitment domain (CARD) and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein releasing its mature activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq Jul 2008]

Gene Symbol:   APAF1
Gene Name:   apoptotic peptidase activating factor 1
Aliases:   APAF-1, CED4, DKFZp781B1145
RefSeq:   NC_000012.11 NT_029419.12
Ensembl:   ENSG00000120868
Entrez:   317
Chromosome Mapping:   12q23

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