PrimePCR™ Probe Assay: CTTN, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0024985
Assay Design:   Exonic
Chromosome Location:   11:70281701-70282393question
Amplicon Length:   125
Splice Variants Targeted:   ENST00000346329 ENST00000301843 ENST00000376561 ENST00000538675

Gene Information

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq May 2010]

Gene Symbol:   CTTN
Gene Name:   cortactin
Aliases:   EMS1, FLJ34459
RefSeq:   NC_000011.9 NT_167190.1
Ensembl:   ENSG00000085733
Entrez:   2017
Chromosome Mapping:   11q13

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