PrimePCR™ Probe Assay: CDK5R1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: CDK5R1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: CDK5R1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0054465
Assay Design:   exonic
Chromosome Location:   17:30815332-30815465question
Amplicon Length:   104
Splice Variants Targeted:   ENST00000313401 ENST00000584792

Gene Information

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau which contributes to Alzheimer's disease. [provided by RefSeq Jul 2008]

Gene Symbol:   CDK5R1
Gene Name:   cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Aliases:   CDK5P35, CDK5R, MGC33831, NCK5A, p23, p25, p35, p35nck5a
RefSeq:   NC_000017.10 NT_010799.15
Ensembl:   ENSG00000176749
Entrez:   8851
Chromosome Mapping:   17q11.2

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